SUCNR1 and type 2 diabetes mellitus: Apparently, factors secreted by adipose tissue induce expression of Sucnr1 in macrophages in vitro, while in vivo other factors in adipose tissue in HFD mice further enhance expression of Sucnr1. Future research should evaluate whether SUCNR1 expression in the SVF is similarly increased in people with type 2 diabetes compared with controls, especially as our data revealed higher SUCNR1 mRNA levels in the SVF vs adipocytes in humans.