APOE and ischemic stroke: Although the protective effect of CN‐105 appears to be time‐dependent, our study was focused on delineating the early mechanistic effects of CN‐105 in ischemic stroke, and did not test the effects of higher drug dosage or multiple dosing, which have increased efficacy in prior studies.32 Since CN‐105 does not include the polymorphic region of the apoE holoprotein, the differential effects of ApoE isoforms were not investigated.