PPIA and ischemic stroke: ApoE appears to protect cerebrovascular integrity in acute brain injury through maintenance of the BBB, as demonstrated in apoE‐deficient mice, which was associated with an increase in disruption of BBB after injury.67, 68, 69 More recently, it has been found that apoE stabilizes BBB through suppression of cyclophilin A (Peptidylprolyl cis‐trans isomerase A or CypA) in an isoform‐specific manner via interaction with LRP1.57 We observed, through our phosphoproteomic study, that CN‐105 downregulated phosphorylation of CypA in ischemic stroke.