Many HBV integration events occurred near or within fragile sites and other repetitive regions, such as TERT, FN1, MLL4, ROCK1, CCNE1, SENP5 (Jiang Z. et al., 2012; Sung et al., 2012; Hai et al., 2014), Alu sequences, and microsatellites, which are prone to tumor development and progression (Feitelson and Lee, 2007). This evidence concerns the gene SENP5 and neoplasm.