The second hit response toward LPS was prevented in LPAR1-deficient rats with BPD for IL-6 (12.0-fold; p < 0.001), MCP-1 (3.6-fold; p < 0.01), PAI-1 (5.1-fold; p < 0.001), and TF (1.5-fold; p < 0.01), whereas CINC1 showed a tendency toward lower levels than LPS-stimulated Wistar rats with BPD. Here, LPAR1 is linked to bronchopulmonary dysplasia.