LPAR1 and bronchopulmonary dysplasia: This prompted us to investigate: [1] the role of LPAR1-deficiency on normal lung development, [2] the acute inflammatory response to LPS of adult rat survivors of BPD, and [3] the beneficial effects of LPAR1-deficiency on the development of a second hit response against LPS-induced acute lung injury in adult rats with hyperoxia-induced BPD.