These include BDNF, CNTF, GDNF, IGF-1, VEGF, FGF; HGF, BMP-7, and G-CSF (for an excellent review of neurotrophic factors both in preclinical development and in CTs in ALS refer to Henriques et al. (2010). The gene discussed is BDNF; the disease is amyotrophic lateral sclerosis.