These include BDNF, CNTF, GDNF, IGF-1, VEGF, FGF; HGF, BMP-7, and G-CSF (for an excellent review of neurotrophic factors both in preclinical development and in CTs in ALS refer to Henriques et al. (2010). This evidence concerns the gene VEGFA and amyotrophic lateral sclerosis.