To discover whether CCNE2 reversed miR-370-mediated blocking of glioma U87 and U251 cells’ malignant evolution in a sequence-specific manner, we analyzed proliferation, migration, invasion and apoptosis of U87 and U251 which stably expressed miR-370 + CCNE2 (non-3′UTR). The gene discussed is CCNE2; the disease is central nervous system cancer.