KCNQ1OT1 and central nervous system cancer: As Figures 1A,B showed, the expression of KCNQ1OT1 in glioma tissues and cell lines was robustly up-regulated in glioma tissues (P < 0.01), U87 and U251 cells (P < 0.05), and was positively correlated with the histopathological grades of gliomas.