KIRREL3 and Jacobsen syndrome: Importantly, in case of NEPH2/KIRREL3 gene in human chromosome 11q24.2, point mutations and chromosomal abnormalities were identified in autism spectrum disorders, intellectual disability and Jacobsen syndrome characterized by neurocognitive delay (Bhalla et al., 2008; Guerin et al., 2012; Michaelson et al., 2012; Talkowski et al., 2012), suggesting its important roles in brain.