CTNND2 and Anxiety: Anxiety and EAE-related traits have been investigated in the rat NIH HS (Hansen and Spuhler, 1984) and QTLs were identified where a single candidate gene was identified by merge analysis (Rat Genome Sequencing and Mapping Consortium et al., 2013; Baud et al., 2014a): Ctnnd2 (catenin delta-2) is associated with conditioned anxiety and Fam198b is associated with weight loss as a result of EAE.