As a proof of concept, a BRCA1 breast cancer model shown to respond to a combination of cisplatin with PARP inhibition (Rottenberg et al., 2008) with further benefit provided by long-term PARP inhibition (Jaspers et al., 2013), led to the US Food and Drug Administration (FDA) approving such a regime for treatment of platinum-sensitive relapsed ovarian cancer (Ledermann et al., 2012; Matulonis et al., 2016). Here, BRCA1 is linked to breast carcinoma.