In addition, R10015 minimally inhibited the early steps of vesicular stomatitis virus (VSV) G-pseudotyped HIV, even at 100 μM (Fig. 4A and E), confirming that the inhibition of HIV did not result from nonspecific cytotoxicity and is indeed specific to viral processes related to HIV gp120-mediated fusion and entry (44); HIV gp120-mediated infection of human CD4 T cells has been known to require cortical actin dynamics (8). Here, CD4 is linked to infection.