However, previous siRNA knockdown studies have demonstrated that the knockdown of LRRK2 or P70S6K did not inhibit HIV infection; the knockdown of FLT3, PKA, or ROCK2 also had no significant impact on HIV replication (55, –, 57), whereas shRNA or siRNA knockdown of LIMK has been shown to inhibit HIV (11, 14; L. C. Zony and B. K. Chen, presented at the 2015 Meeting on Retroviruses, Cold Spring Harbor Laboratory, 18 to 23 March 2015, Cold Spring Harbor, NY, USA). Here, LRRK2 is linked to HIV infectious disease.