Actually, c-MYC is typically amplified in HPV16 cervical squamous cell carcinomas [25, 26], and its binding to the consensus DNA element is reported to be methylation-sensitive, in particular at CpG islands and nearby regions, supporting our finding of an interaction at hypomethylated regions at CpG island shores [27, 28]. The gene discussed is MYC; the disease is cervical squamous cell carcinoma.