Subjects with T2DM had significantly higher PAPP-A concentrations (19.3 ± 16.4 vs. 13.3 ± 13.9 ng/ml, p < 0.001) and hsCRP levels (8.4 ± 5.9 vs. 6.5 ± 5.7 ng/ml, p < 0.001) than those without. This evidence concerns the gene PAPPA and type 2 diabetes mellitus.