Furthermore, as shown in Table 4, when PAPP-A was combined with other factors, the AUC improved to 0.83 (95% CI 0.75–0.91) in subjects with T2DM, 0.83 (95% CI 0.77–0.89) in all subjects, and 0.80 (95% CI 0.70–0.90) in those without T2DM. Here, PAPPA is linked to type 2 diabetes mellitus.