EFEMP1 and central nervous system cancer: The multiple genotypes, such as glioma, was a result of many gene polymorphism, gene- gene interactions, considering CCND1 G870A polymorphism and EFEMP1both are risk factor of glioma in previous literatures, but no study focused on this the interaction between CCND1 G870A polymorphism and EFEMP1 polymorphisms.