NOTCH3 and acute lymphoblastic leukemia: Our data showed that CCL25 and Wnt5a changed MOLT4 cell distribution in bone marrow and liver in some extent, but this is not the unique mechanism, several other pathway have been proved to related with T-ALL metastasis, such as Notch1 pathway [46], Notch3 pathway [47], IL-7/IL-7R signaling [48] and CCL19/CCR7 signaling [49].