AFAP1 and cancer: In a previous study, we performed gene expression profile (GEP) analysis by microarray and found that one lncRNA named actin filament-associated protein 1 antisense RNA1 (AFAP1-AS1) was significantly upregulated in nasopharyngeal carcinoma (NPC), and promoted invasion and metastasis of cancer cells by regulating the expression of several small GTPase family members and molecules in the actin cytokeratin signaling pathway [18].