Interestingly, using the GEO database, we found and confirmed that the expression of AFAP1-AS1 is positively correlated with PD-1, that high expression of PD-1 and AFAP1-AS1 predicts high incidence of recurrence or metastasis and that co-expression of AFAP1-AS1 and PD-1 in NPC biopsies predicted the poorest prognosis. Here, AFAP1 is linked to nasopharyngeal carcinoma.