Since so many biological mechanism are related to epilepsy, we are interested in the current research status that miR-132/212 had been involved in epilepsy, Pubmed search found 15 papers about these neurimmiRs participated in epilepsy, such as BDNF/TrkB pathway and p250GAP/Cdc42 signaling have been researched, BDNF/Trkb can be adjusted by PI3K and MAPK pathways, which is accorded with the above analysis. The gene discussed is BDNF; the disease is epilepsy.