The EGFR mutation was the most common mutation detected in the tumor tissue of NR group and was identified in all of the 6 cases (100%), including 3 cases of EGFR 19-Del, 1 case of a co-mutation of EGFR L858R and EGFR V689V, 1 case of EGFR 746-756 Del and ZNF385D-ROS1 fusion, and 1 case of EGFR M766 delins MASV.(Table 4 and Figure 3) The unique mutation in the marginal tissue in the NR group was identified in patient #12. This evidence concerns the gene EGFR and neoplasm.