STXBP2 and obesity due to melanocortin 4 receptor deficiency: We examined the relation of rs188212047 of STXBP2 and the other eight SNPs found to be related (P < 0.01) to MI to intermediate phenotypes of MI—including hypertension, diabetes mellitus, hypertriglyceridemia, hypo–HDL-cholesterolemia, hyper–low density lipoprotein (LDL)–cholesterolemia, chronic kidney disease, obesity, and hyperuricemia—with the use of Fisher's exact test or Pearson's chi-square test.