STXBP2 and Familial hemophagocytic lymphohistiocytosis: Mutations in STXBP2 are associated with familial hemophagocytic lymphohistiocytosis (FHL), a life-threatening hyperinflammatory syndrome that results from an uncontrolled and ineffective immune response due to dysfunction of cytotoxic T lymphocytes (CTLs) and NK cells [18–20].