Given that vascular inflammation is an important contributor to the development of coronary atherosclerosis and thrombosis [24, 25] and that STXBP2 is implicated in the regulation of inflammation and the immune response [18–23], the association of rs188212047 [G/T (L212F)] of STXBP2 with MI might be attributable to the effect of this gene on vascular inflammation. This evidence concerns the gene STXBP2 and myocardial infarction.