Under certain pathologic conditions, Casp12 is expressed in human tissues, including proximal tubule cells of kidney [15] and cancers such as Hep-J5 cells [16, 17], multiple myeloma [18], gastrointestinal stromal tumor [19], glioblastoma [12] and NPC cells [13], suggesting a selective advantage in cancer cells [20]. This evidence concerns the gene CASP12 and cancer.