From the subgroup results, we found that UCA1 was a significant prognostic indicator of OS for patients with esophageal cancer (HR: 2.41, 95 % CI: 1.01-3.82, p<= 0.001), gastric cancer (HR: 2.13, 95 % CI: 1.17-3.09, p<= 0.001), colorectal cancer (HR: 2.21, 95 % CI: 1.35–3.08, p<= 0.001), pancreatic cancer (HR: 1.58, 95 % CI: 1.01–2.15, p<= 0.001). This evidence concerns the gene UCA1 and esophageal cancer.