Although B-cell lymphomas with T-cell markers other than CD5, such as CD8+ CLL [5–13] or CD2/CD3/CD4/CD7/CD8+ large B-cell lymphoma [13–31] have been reported (Table 1), data regarding their frequency, histopathological distribution, and clinical features are rarely available, because the number of identified cases in each report is small. The gene discussed is CD8A; the disease is B-cell chronic lymphocytic leukemia.