GAPDH and oral cavity squamous cell carcinoma: The effect of nitric oxide on glycolysis is complicated and appears to be context dependent [13]: nitric oxide promotes glycolysis by sustaining HIF-1α protein stability in oral squamous cell carcinoma [14] while, under inflammatory state, high dose nitric oxide derived from iNOS inhibits glycolysis by S-ntirosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [15].