Recently, Zhou et al. (32) published a meta-analysis involving 10 prospective studies with 29,366 participants, reporting the clinical utility of urinary concentration of NGAL as an independent predictor of ESKD among patients with CKD (pooled adjusted RR: 1.40; 95%CI=121–1.61; P<0.001); urinary KIM-1 exhibited a borderline significance (pooled adjusted RR: 1.13; 95%CI=1.00–1.27; P=0.057) as an independent predictive factor of CKD stage 3. This evidence concerns the gene LCN2 and chronic kidney disease.