As another example, in renal grafts, KIM-1 mRNA signaling was increased in biopsies with interstitial fibrosis and tubular atrophy (IF/TA) vs in specimens with acute calcineurin inhibitor toxicity or acute rejection, and KIM-1 mRNA in urine cells was also increased in patients with IF/TA, which shows its potential as a biomarker of injuries that can trigger intragraft fibrosis (38). This evidence concerns the gene HAVCR1 and Atrophy.