Logistic regression analyses with each of the initial and day-2 level of sRAGE, CC16, SP-D, CYFRA21-1, and KL6/MUC1 as the single predictor variable and the occurrence of ARDS as the dependent binary variable respectively provided significant results solely for the initial level of CC16 (OR, 1.93; 95% CI, 1.08–3.47; p = 0.027) and the initial level of CYFRA21-1 (OR, 1.68; 95% CI, 1.09–2.60; p = 0.019). Here, SFTPD is linked to acute respiratory distress syndrome.