Logistic regression analyses were performed with each of the initial and day-2 level of sRAGE, CC16, SP-D, CYFRA21-1, and KL6/MUC1 as single predictor variable and the event “occurrence of pneumonia” as binary dependent variable, obtaining significant results for the initial CC16 level (OR, 2.21; 95% CI, 1.18–4.12; p = 0.013), the initial CYFRA21-1 level (OR, 1.83; 95% CI,1.15–2.89; p = 0.010), the day-2 CC16 level (OR, 2.68; 95% CI, 1.28–5.59; p = 0.009), and the day-2 CYFRA21-1 level (OR, 1.91; 95% CI, 1.08–3.36; p = 0.026). The gene discussed is SFTPD; the disease is pneumonia.