To test the hypothesis that antioxidant protection triggered by a blood meal could influence a mosquito’s infection status with different flavivirues, we challenged catalase-silenced Aedes aegypti with two doses of Zika virus and measured the number of PFU per midgut (infection intensity) and the number of infected midguts (infection prevalence) seven days after administration of virus-contaminated blood. Here, CAT is linked to infection.