CAT and infection: However, we observed a significant reduction in infection prevalence (70% of dsLacZ mosquitoes were infected vs 46% of dsCatalase; p = 0.0006 ±chisquare, demonstrating that a reduction in epithelial H2O2-removing capacity through catalase knockdown reduced the ability of Dengue-4, but not Zika virus, to infect the midgut of Aedes aegypti.