KLK3 and neoplasm: In a previous study we showed that total and index tumor extent were significantly associated with higher preoperative prostate specific antigen (PSA), clinical stage T2, pathological stage greater than T2, positive surgical margin (PSM) and higher radical prostatectomy (RP) Gleason score (1).Total and index tumor extent predicted time to biochemical recurrence (TBCR) following RP on univariate analysis.