RRM2 and cancer: Three of these domains, RRM1, RanBP2-type ZnF and RRM2, whose individual structures have been recently deposited in the PDB (Figure 1B, accession codes: 2LXI, 2MXV and 2M2B respectively) are sequentially positioned in the N-terminal part of RBM10 creating a long RNA recognition region (Figure 1A) and deletions and mutations of these domains have been linked to cancer (6,9,12).