Most of the identified proteins associated with PD, including α-synuclein, PINK1, Parkin, LRRK2, DJ-1, and VPS35, are localized to mitochondria or mitochondria-associated ER membranes (MAM) [31,116,120,121,122,123], indicating that these PD associated proteins might be regulators of mitochondrial dynamics, including fusion, fission, and trafficking in general. The gene discussed is PRKN; the disease is Parkinson disease.