Notably, we have shown that the expression of Miro1 is significantly decreased in the spinal cords of ALS patients and mutant SOD1 and TDP-43 transgenic mice [153], therefore indicating the possibility that Miro1 downregulation likely contributes to mitochondrial movement abnormalities in ALS and ALS experimental models. Here, TARDBP is linked to amyotrophic lateral sclerosis.