Taddesse-Heath et al. reported four cases with overlapping clinical findings between PBL and PCM, all with histological and phenotypical features of PBL, complex karyotype, and c-MYC rearrangement, which suggested that c-MYC dysregulation contributes to the plasmablastic morphology and aggressive clinical behavior in terminally differentiated B-cell neoplasms [124]. This evidence concerns the gene MYC and B-cell neoplasm.