Burkitt lymphoma as well as DLBCL with c-MYC rearrangement usually show diffuse, strong nuclear or nuclear/cytoplasmic immunohistochemical staining for c-MYC in the majority of cells, while DLBCLs without c-MYC rearrangement typically only show a subset of positive cells (<40% lymphoma cells) or nonspecific cytoplasmic staining [54,55]. This evidence concerns the gene MYC and Burkitt lymphoma.