MYC and Burkitt lymphoma: In sporadic BL, the IGH enhancer intron is on the opposite chromosome of the translocation and is not able to drive c-MYC expression; instead, the enhancers at 3′ end of the immunoglobulin heavy chain and kappa light chain genes are always located on the same chromosome as c-MYC and likely lead to c-MYC deregulation [63].