A complex karyotype with c-MYC rearrangement, especially with chromosomal partners other than one of the immunoglobulin gene loci (chromosomes 14q, 2p and 22q) can indicate genomic evolution of the lymphoma cells into a high-grade B-cell lymphoma, NOS rather than development of Burkitt lymphoma [45]. This evidence concerns the gene MYC and Burkitt lymphoma.