c-MYC protein expression identified by immunohistochemistry is commonly seen in low-grade B-cell lymphomas, including FL, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and splenic, extranodal, or nodal marginal zone lymphoma, but nearly always in a minority of lymphoma cells (<25%) [53]. Here, MYC is linked to B-cell chronic lymphocytic leukemia.