MYC and B-cell non-Hodgkin lymphoma: As BCL2 rearrangement is the one of the two “hits” in double-hit lymphoma, acquisition of c-MYC rearrangement during disease progression leads to histologic transformation to high-grade B-cell lymphoma/DHL and rarely plasmablastic lymphoma or blastoid transformation of FL/B-lymphoblastic lymphoma [101,161,162].