STAT3 and lymphoma: In Hummel’s study, the genes in the mBL signature were composed of 58 genes, including several target genes of the NF-κB pathway, such as B-cell lymphoma protein 2A1 (BCL2A1), FLICE-like inhibitory protein (FLIP), cluster designation 44(CD44), nuclear factor κBIA (NFKBIA), B-cell lymphoma 3 protein (BCL3), and signal transducer and activator of transcription 3 (STAT3), that all can be used to distinguish activated B-cell–like or germinal-center B-cell–like lymphomas [72].