Earlier studies in the neuromuscular field reported interesting, although somewhat conflicting results from experimental clinical trials where two classes of ASOs (a 2′-O-methyl and a phosphorodiamidate morpholino) were used to rescue the dystrophin protein synthesis in Duchenne Muscular Dystrophy (DMD) via splicing modulation [6]. This evidence concerns the gene DMD and Duchenne muscular dystrophy.