In a recent paper Goyenvalle and collaborators showed that tc-DNA ASO was able to improve cardio-respiratory and neuromuscular functions in two DMD mouse models: the mdx mouse model, and the Utrn (encoding utrophin)-Dmd double knockout mouse model which develops even more severe muscular dystrophy than the mdx model [64,65,66]. Here, DMD is linked to Duchenne muscular dystrophy.