As galanin receptor 2 may play an important role in nociceptive modulation in the central nervous system, the present study was further to explore the role of galanin receptor 2 in pain modulation in ACC of rats and found that the selective galanin receptor 2 antagonist M871 attenuated the galanin-induced antinociceptive effects in ACC, suggesting that galanin receptor 2 is involved in the galanin-induced antinociceptive effects in ACC in both normal rats and rats with mononeuropathy. This evidence concerns the gene GALR2 and adrenal cortex carcinoma.