PTEN and melanoma: A recent genomic study of 23 pediatric melanomas revealed that adolescent and adult conventional melanomas are similar in that both (i) have a high burden of ultraviolet-induced signature mutations, (ii) commonly harbor activating mutations in BRAF and the TERT promoter, and (iii) commonly harbor inactivating alterations of the CDKN2A and PTEN tumor suppressor genes32.