A recent genomic study of 23 pediatric melanomas revealed that adolescent and adult conventional melanomas are similar in that both (i) have a high burden of ultraviolet-induced signature mutations, (ii) commonly harbor activating mutations in BRAF and the TERT promoter, and (iii) commonly harbor inactivating alterations of the CDKN2A and PTEN tumor suppressor genes32. Here, BRAF is linked to melanoma.