Given the association of TERT promoter mutations with adverse outcome in adult melanoma patients22, we investigated the prognostic value of these mutations, as well as promoter hypermethylation− an epigenetic alteration linked to TERT upregulation in a subset of melanomas29, using 28 tissue specimens from a well-annotated cohort of 27 AYA melanomas at the University of Pittsburgh. The gene discussed is TERT; the disease is melanoma.