Since the frequency of the TERT-independent Alternative Lengthening of Telomere mechanism in melanoma is low45, and since genomic rearrangement involving TERT is another mechanism for upregulation of this gene46, we tested whether a subset of the AYA cases harbored such rearrangements, including those cases which lacked mutated or hypermethylated TERT promoter. This evidence concerns the gene TERT and melanoma.