On the other hand, dysregulation of NF-κB, resulting in constitutive activation of NF-κB signaling, causes massive inflammatory damage to the host, which may lead to autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, and inflammatory bowel diseases3, 4. This evidence concerns the gene NFKB1 and rheumatoid arthritis.