On the other hand, dysregulation of NF-κB, resulting in constitutive activation of NF-κB signaling, causes massive inflammatory damage to the host, which may lead to autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, and inflammatory bowel diseases3, 4. The gene discussed is NFKB1; the disease is systemic lupus erythematosus.