Forty-one patients (28%) showed HFSR, 21 patients (15%) had diarrhea, 29 patients (20%) had hypertension, 38 patients (26%) had skin rash, 65 patients (45%) had fatigue, 18 patients (12%) had increased AST/ALT, 15 patients (10%) had increased bilirubin, 13 patients (9%) showed hypothyroidism. This evidence concerns the gene GPT and hypertensive disorder.