On the other hand, the α-cell specific Siglec-3 showed a substantial increase in diabetes upon normalization against cyclophilin (PPIA), glucagon or SAT2 (Fig. 2A; induced to 5.15-, 4.29-, 5.52-fold, respectively in individuals with T2D, vs. non-diabetic controls). The gene discussed is GCG; the disease is type 2 diabetes mellitus.