While screening for functional CD47 cis-regulatory regions (enhancers or constituent enhancers within SEs), we discovered that (i) a functional enhancer (E7), located upstream CD47, had enhancing activity that was common to all the cancer cell lines tested; (ii) two functional constituent enhancers, E5 present within a downstream CD47-associated SE and E3.2 present within an upstream CD47-associated SE, are to date only active in MCF7 breast cancer cells or Jurkat T-ALL cells respectively. Here, CD47 is linked to breast cancer.