Similarly, we also demonstrated that HIF‐1α was increased in fibrotic livers in vivo (Fig. 6), which was consistent with previous reports 5, 6; however, PlGF‐specific siRNA inhibited the expression of HIF‐1α in fibrotic livers (Fig. 6), thus leading to the decreased liver fibrosis and angiogenesis. The gene discussed is PGF; the disease is Hepatic fibrosis.