In our current study, all the patients showed higher serum level of TSH, TgAb, Tg, and calcitonin after surgery and radiation therapy as shown in Table 3, while 9 days of Escin treatment significantly reduced the serum levels of all these four biomarkers close to the normal level of healthy volunteers suggesting Escin might benefit all subtypes of thyroid cancer. Here, CALCA is linked to thyroid cancer.