As TSH, TgAb, Tg, and calcitonin increasing are well‐known indicators for thyroid cancer recurrence and Escin is shown to be able to decrease these indexes simultaneously, it became very interesting to see whether the effects Escin on these indicators would lead to benefits on long‐term survive rate of patients with advanced thyroid cancer. The gene discussed is CALCA; the disease is thyroid gland carcinoma.