Indeed, as shown in Table 3, after 9‐day Escin treatments TSH level dropped from 1.87 ± 0.64 IU/L to 1.1 ± 0.34 IU/L, TgAb level dropped from 54.9 ± 8.14 IU/mL to 44.77 ± 4.28 IU/mL, TBG level dropped from 78.19 ± 7.23 μg/L to 54.1 ± 6.87 μg/L, and calcitonin level dropped from 198.32 ± 35.98 ng/L to 124.32 ± 28.32 ng/L, respectively, suggesting Escin treatment might regulate the thyroid function in patients with thyroid cancer. This evidence concerns the gene CALCA and thyroid cancer.