Performing a multivariate analysis of recurrence risk by treatment, metastatic site and subtype (Table 4), no difference was seen for LRR between Luminal B HER2 and HER2+(ER−) cancer in Trast –ve patients (OR 1.39, 95% CI 0.47–4.5: p = 0.557). This evidence concerns the gene ERBB2 and cancer.