Luminal B HER2 cancers had a statistically significant improvement in both 5-year DFS (p < 0.001) and OS (p < 0.001) (Fig. 1a, b), while the HER2+(ER−) only had a significant improvement in DFS (p = 0.012) but not OS (p = 0.135) (Fig. 1c, d). This evidence concerns the gene ERBB2 and cancer.