NPPB and hydrops fetalis: The interpretation of BNP testing in patients with acute dyspnea will depend on whether or not patients have received sacubitril/valsartan, although the relative increases in plasma BNP concentrations in patients treated with sacubitril/valsartan in the PARADIGM-HF trial were modest (from a median of approximately 200 ng/L at baseline to approximately 225 ng/L at 8 months) [12, 55].