WIF1 and cervical carcinoma: It has been recently observed that WIF1 (Wnt inhibitory factor 1) is downregulated in Ca ex PA and that when overexpressed it increases expression of pri-let-7a, a primary transcript of let-7a [20]. miR-133b has been downregulated in many tumours and upregulated only in cervical carcinoma, where it acts as an oncogene to promote tumorigenesis and metastasis.