C3 and non-small cell lung carcinoma: For example, in 2015, Lee [33] and colleagues identified 8 human SNPs significantly associated with NSCLC prognosis, including CD3EAP rs967591, TNFRSF10B rs1047266, AKT1 rs3803300, C3 rs2287845, HOMER2 rs1256428, GNB2L1 rs3756585, ADAMTSL3 rs11259927, and CD3D rs3181259.