Additionally, other compounds identified in the propolis such as caffeic acid, apigenin, and triterpenes are descript with important blockers of oncogenic kinase PAK1, well known to be responsible for a variety of diseases such as infectious diseases, Alzheimer's disease, diseases inflammatory, diabetes, hypertension, obesity, and cancer [31]. This evidence concerns the gene PAK1 and early-onset autosomal dominant Alzheimer disease.