HLA-G interaction with ILT2 and CD94/NKG2A results in the inhibition of NK-cell cytotoxicity, IFN-γ secretion, and chemotaxis (43), while sMICA–NKG2D binding impairs NK-cell tumor-specific cytotoxicity, NKG2D expression, and homeostatic maintenance (42). This evidence concerns the gene HLA-G and neoplasm.