Downregulation of vacuolar sorting protein HRS in L. donovani-infected macrophages prevents uncoupling of mRNA-AGO2 interaction, blocking degradation of translationally repressed messages. let-7a miRNPs fail to repress newly formed IL-6 mRNA. Translation of IL-6 helps Leishmania to suppress host macrophage activation and promote infection. Here, IL6 is linked to infection.