Oral administration of YKS ameliorated increased aggressiveness and decreased social behaviors in transgenic mice expressing human amyloid precursor protein (hAPP) (Fujiwara et al., 2011), rats and mice subjected to thiamine deficiency (Ikarashi et al., 2009; Iizuka et al., 2010; Yamaguchi et al., 2011), and serotonin (5-HT)-deficient rats (Kanno et al., 2009), as measured by social interaction tests. Here, APP is linked to Thiamine deficiency.