Moreover, palmitate-induced insulin resistance was accompanied with enhanced ER stress (Figure 2A), which has been suggested a major contributor to palmitate-induced insulin resistance through ER stress-activated JNK/IRS-1 pathway (Chan et al., 2013; Simon-Szabó et al., 2014; Tang et al., 2015; Park et al., 2016). The gene discussed is MAPK8; the disease is Insulin resistance.