INS and diabetes mellitus: Curcumin, a major bioactive component from ancient medicinal herb Curcuma longa L., has shown strong ability to improve diabetes and diabetic complications, due to its physiological and pharmacological properties such as anti-oxidative stress, anti-inflammation, and anti-insulin resistance activities (Jeenger et al., 2015; Nabavi et al., 2015; Rivera-Mancía et al., 2015).