TDP43 aberrant protein inclusions have been reported in 80% of ALS cases and it seems that the cytoplasmic accumulation is due to mutations in the 3′ UTR region of the genes, which lead to overexpression and altered location of the protein (Neumann et al., 2006; Coan and Mitchell, 2015). Here, TARDBP is linked to amyotrophic lateral sclerosis.