Overexpression of either the human FMRP (FMR1 gene) or the native Drosophila dFMRP (dfmr1 gene) fully rescues all detectable disease-like phenotypes in the Drosophila FXS model (Coffee et al., 2010), confirming the evolutionary conserved functions of FMR1 in the nervous system. This evidence concerns the gene FMR1 and fragile X syndrome.