APP and Alzheimer disease: Meanwhile, some other pathological proteins in Alzheimer's disease such as amyloid precursor protein, presenilin, phosphorylated tau protein, and brain-derived neurotrophic factor are associated with Aβ deposition and contribute to the regulation of neuronal function in Alzheimer's disease (Saura et al., 2004; Schindowski et al., 2008; Peethumnongsin et al., 2010).